Future research is also needed to explore the exercise dosage and program components that result in optimal improvements in health-related quality of life. Since our study was a pilot study with a small sample size, future randomized controlled studies with adequate sample sizes are needed to examine further the effect of HIIT+RT on health-related quality of life in CLL. Since you and your colleagues conclude from the pilot study findings that, "twelve weeks of HIIT+RT may improve and maintain HRQOL components before patients require therapies that typically worsen their quality of life," what additional research still needs to be performed to corroborate this potential benefit? establishing ways to integrate an exercise program into clinical care practice. ![]() determining the optimal exercise mode and dosage needed to improve treatment-related effects, health, and quality of life outcomes and.determining the ideal time to implement an exercise program after cancer diagnosis.identifying strategies to tailor the exercise intervention to the individual needs of each patient.Methodological challenges in exercise oncology studies include: What are the methodological challenges in exercise oncology studies? ![]() Therefore, for optimal improvements in health-related quality of life, especially concerning fatigue and symptom burden, an exercise program consisting of both HIIT and resistance training may be ideal. Previous studies have suggested that combining HIIT with resistance training may be more beneficial for reducing fatigue and symptom burden than a program that only includes HIIT. HIIT+RT also resulted in clinically meaningful improvements in functional well-being, general well-being, and symptoms specific to CLL.Ĭan you expound on the comment in your report that HIIT, when combined with resistance training, could optimize health-related QOL benefits? We found that the patients who participated in the HIIT+RT intervention had significant improvements in functional well-being-for example, people’s ability to perform their day-to-day tasks-compared to the control group. Therefore, we implemented a 12-week HIIT+RT intervention in patients with CLL.Ĭan you briefly explain the findings you and your colleagues observed that support the use of HIIT+RT in improving health-related QOL in older individuals with CLL (mean age: 64 years) 1 ? In addition, previous research has suggested that combining HIIT with resistance training may be more beneficial for reducing fatigue and symptom burden than just HIIT alone. HIIT may be a practical option for patients with CLL as it is a safe training mode when prescribed by experts, and it can rapidly improve fitness with lower training time and volume compared to moderate-intensity aerobic programs. Therefore, there is a need to find strategies to address some of these CLL-related issues to ultimately improve quality of life. What was the rationale for the pilot study?ĬLL is associated with an increased risk for infections, co-morbidities, low cardiorespiratory fitness, and impaired physical function-all of which can reduce overall quality of life. ![]() ![]() 1 Findings for the effects of the HIIT+RT program on physical fitness and immunological function in CLL were published in 2021 in Scientific Reports. 1 Results pertaining to health-related QOL were published online ahead of print in September in the Journal of Geriatric Oncology. To narrow this research gap, researchers from Duke University and the University of North Carolina conducted a pilot study to investigate the potential benefits of an exercise intervention consisting of 12 weeks of HIIT+RT on several outcomes, including health-related QOL, among older adults with treatment-naïve CLL. HIIT+RT also resulted in clinically meaningful improvements in functional well-being, general well-being, and symptoms specific to CLL." –Andrea Sitlinger, MD, David Bartlett, PhD, and Ashley Artese, PhD, Duke University "We found that the patients who participated in the HIIT+RT intervention had significant improvements in functional well-being-for example, people’s ability to perform their day-to-day tasks-compared to the control group.
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